itching may:
* Affect large areas of the body
* Be worse at night
* Occur without an obvious rash
* Affect the back, arms, legs, or face
* Interfere with sleep
* Become worse after scratching
Because many conditions can cause itching—including allergies, eczema, liver disease, medications, and dry skin—it should not automatically be blamed on the kidneys.
## 3. Darkening or Changes in Skin Color
Advanced chronic kidney disease can sometimes be associated with changes in skin pigmentation.
NIDDK lists **darkened skin** among symptoms that may occur as CKD becomes more advanced.
The skin may
